Product Name :
KAPPA LIGHT CHAIN
Clinical Significance :
The determination of Kappa light chain in human serum is important for the d iagnosis and sub typing of monoclonal gammopathies. These help in the d ifferentiation of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Polyclonal immunoglobulins exhibit both Kappa and Lambda types of light chains in a roughly constant ratio of 2:1, whereas monoclonal immunoglobulins exhibit only one type of light chain. Increased production of monoclonal immunoglobulins or free monoclonal light chains leads to a Kappa/ Lambda quotient outside the reference range indicating the existence of a monoclonal gammopathy.
Intended Use :
This reagent is used for the invitro quantitative determination of Kappa Light Chain (KLC) inhuman serum by nephelometric immunoassay.
Nephelometry methodology Linear up to 800 mg/dL Ready to use reagents
No calibration required
Lower detection level 40 mg/dL
Intended Use
This reagent is used for the invitro quantitative determination of Kappa Light Chain (KLC) inhuman serum by nephelometric immunoassay.
Nephelometry methodology Linear up to 800 mg/dL Ready to use reagents
No calibration required
Lower detection level 40 mg/dL
Clinical Significance
The determination of Kappa light chain in human serum is important for the d iagnosis and sub typing of monoclonal gammopathies. These help in the d ifferentiation of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Polyclonal immunoglobulins exhibit both Kappa and Lambda types of light chains in a roughly constant ratio of 2:1, whereas monoclonal immunoglobulins exhibit only one type of light chain. Increased production of monoclonal immunoglobulins or free monoclonal light chains leads to a Kappa/ Lambda quotient outside the reference range indicating the existence of a monoclonal gammopathy.
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