Product Name :
LAMBDA LIGHT CHAIN
Clinical Significance :
The determination of Kappa/Lamda light chains in human serum is important for the d iagnosis and sub typing of monoclonal gammopathies. These help in the d ifferentiation of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Polyclonal immunoglobulins exhibit both Kappa and Lambda types of light chains in a roughly constant ratio of 2:1, whereas monoclonal immunoglobulins exhibit only one type of light chain. Increased production of monoclonal immunoglobulins or free monoclonal light chains leads to a Kappa/ Lambda quotient outside the reference range ind icating the existence of a monoclonal gammopathy.
Intended Use :
This reagent is used for the invitro quantitative determination of Lamda Light Chain (LAM) inhuman serum by nephelometric immunoassay.
Nephelometry methodology
-Linear up to 400 mg/dL
-Ready to use reagents
-No calibration required
-Lower detection level 40 mg/dL
Intended Use
This reagent is used for the invitro quantitative determination of Lamda Light Chain (LAM) inhuman serum by nephelometric immunoassay.
Nephelometry methodology
-Linear up to 400 mg/dL
-Ready to use reagents
-No calibration required
-Lower detection level 40 mg/dL
Cl inical Significance
The determination of Kappa/Lamda light chains in human serum is important for the d iagnosis and sub typing of monoclonal gammopathies. These help in the d ifferentiation of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Polyclonal immunoglobulins exhibit both Kappa and Lambda types of light chains in a roughly constant ratio of 2:1, whereas monoclonal immunoglobulins exhibit only one type of light chain. Increased production of monoclonal immunoglobulins or free monoclonal light chains leads to a Kappa/ Lambda quotient outside the reference range ind icating the existence of a monoclonal gammopathy.
Principle
Lambda light chain in the serum sample reacts on a specific antibody and develop turbid ity by the formation of immune complexes which is directly proportional to the concentration of lambda light chain in serum.
Comments