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The APTT reagent is an in vitro diagnostic assay intended for use in determining activated partial thromboplastin time (APTT) on the Mispa Clog Plus Analyzer.
The activated partial thromboplastin time (APTT) is used as a general screening test for the detection of coagulation abnormalities in the intrinsic pathway. The APTT is sensitive to deficiencies or abnormalities of factors VIII, IX, XI, XII, X, and II, prekallikrein, high molecular weight kininogen (HMWK), and fibrinogen. APTT is also sensitive to inhibitors of blood coagulation such as lupus inhibitor and fibrin/fibrinogen degradation products (1).
The APTT is the most widely used method for monitoring intravenous heparin anticoagulation therapy (2, 3).The capacity of blood to form a fibrin clot by way of the intrinsic hemostatic pathway requires coagulation factors I, II, V, VIII, IX, X, XI and XII, platelet lipids and calcium(4). The assay is performed by the addition of a suspension of rabbit brain cephalin with a surface activator(1). The APTT has proven to be a simple and highly reliable measurement of the intrinsic coagulation mechanism(5).